SAN FRANCISCO -- The Carolina Panthers can now say they have that signature win everybody has been waiting to see: on the road, against the reigning NFC champions, in November. While facing one of the NFLs brightest young quarterbacks, to boot. Carolinas swarming, opportunistic defence stopped Colin Kaepernick in his tracks. Drayton Florence intercepted a pass by Kaepernick in the final minute to seal a 10-9 victory Sunday to snap the San Francisco 49ers five-game winning streak and give the Panthers their fifth straight win. So much for the idea that Carolina hadnt beaten any team of consequence thus far. "I dont think it really bothers us, it gives us the opportunity to step up to the challenge. We did," said wide receiver Steve Smith, who had six receptions. "A win like this can boost us, a win like this can continue to give us life throughout the season, and make us feel like were working for something, and we are." Graham Gano kicked a 53-yard field goal with 10:05 remaining that held up as the Panthers (6-3) twice shut down Kaepernick on last-ditch drives with swarming defence. DeAngelo Williams broke two tackles for a 27-yard touchdown run late in the first half that pulled Carolina within 9-7. Gano missed wide left on a 48-yard field goal in the third period, but came through later. San Francisco (6-3) got the ball back with 5:25 left at its 1, then again with 1:02 to go. Phil Dawson kicked a season-best 52-yard field goal among his three for the 49ers, who lost tight end Vernon Davis and rookie safety Eric Reid to concussions. Carolina fumbled twice in the closing moments, but recovered each time. First, Jonathan Stewart fumbled and Mike Tolbert pounced on the ball. Cam Newton recovered his own bobble. This was hardly the highly touted showdown between 2011 No. 1 overall pick Newton and Kaepernick, the sixth quarterback drafted that year, in the second round. They roomed together during the scouting combine. For Newton, the numbers hardly mattered. "This game is a maturity jump for us, because in the past what Ive been a part of, weve been somewhat uncertain of how we will turn out in these types of games," Newton said. "We needed that type of game, just to be in a dog fight, in somewhat of a barnburner, to show what type of team this really is." Kaepernick went 11 for 22 for 91 yards with an interception and was sacked six times for a 42.0 passer rating. Newton was only slightly better, going 16 of 32 for 169 yards, an interception and four sacks for a 52.7 rating. For two teams that have been putting up points at a prolific pace for the past month, the defences dictated this one. "As the game went on, it got more and more intense," Smith said. More than losing the game, the 49ers losses of Davis and Reid could be troublesome for the reigning NFC champions as they hit the road next week for New Orleans, then go to Washington. "Well do what we do, bounce back, regroup, refit and reorganize and come back this week," coach Jim Harbaugh said. Davis didnt return after sustaining a concussion in the second quarter, then Reid went down on a helmet-to-helmet hit on Mike Tolbert in the third. Earlier, Reid recovered a fumble to give him five takeaways in an already-stellar rookie season that also includes three interceptions. Frank Gore had 16 carries for 82 yards, accounting for most of San Franciscos 151 total yards. "For the most part, I dont really think they did anything that necessarily confused us," 49ers centre Jonathan Goodwin said. "They only gave up nine points. Its hard not to give them credit. We expected it to be a physical game. Did we expect to only score nine points? Nah." Dawson put San Francisco ahead on a 52-yard field goal on the teams opening drive, then kicked second-quarter field goals of 43 and 25 yards. But Kaepernick could never get his team in the end zone in its first game since a bye on the heels of a win over Jacksonville in London. 49ers pass-rushing specialist and 2012 All-Pro linebacker Aldon Smith played limited snaps after missing five games to undergo treatment for substance abuse. Wide receiver Mario Manningham started and had three catches in his season debut, nearly 11 months after a serious left knee injury that required surgery. Carolina got going after managing only minus-7 yards passing and 12 total yards in the first quarter. The Panthers finished with 250 total yards. "This one really did come down to the way the defence played," Panthers coach Ron Rivera said. "Any time you put yourself in a position where you can force the other team to kick field goals, you get a chance to win." Notes: The 49ers also lost TE Garrett Celek to a hamstring injury in the first quarter, while DT Ray McDonald hurt an ankle. ... 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Chaussures Pas Cher Chine . -- Augusta James of Bath, Ont.TURRACHER HOHE, Austria - Canadian alpine skier Erik Guay has pushed back his return to competition and will sit out the upcoming world championships.The 33-year-old Olympian from Mont-Tremblant, Que., had surgery to replace cartilage and bone in his left knee in June after undergoing arthroscopic surgery on the same knee in March. His hope was be back on the slopes in January to prepare for the upcoming alpine world championships in Beaver Creek, Colo., the first week of February, however that will not happen.My on-snow training is progressing well at the moment, said Guay in a statement. However Im not ready to return to world cup racing quite yet. Ive been working step by step towards being ready for World Cup competition in January, but after evaluating my progress, together with my team of coaches, weve decided a return to competition at Kitzbuhel is not in the cards.Guay will miss the world championships, continuing his rehabilitation to insure hes 100 per cent ready for competition.My goal was to go into the worldd championships with some world cup racing under my belt and target a podium result at Beaver Creek, nothing less, said Guay.ddddddddddddEvaluating where I am now and what my performance expectation is for the world championships Ive made the difficult decision to forgo the 2015 world championships. Now, we will focus our energies, and continue our program work, progressing toward a return to World Cup racing after the world championship period in late February.Two weeks after his arthroscopic procedure in March, Guay was still experiencing pain and swelling in his knee. Thats when he made the decision to have the more invasive surgery because he needed to get his knee in a good place as he still plans to represent Canada at the 2018 PyeongChang Olympics.Guay, a three-time Olympian, won the mens world downhill championship in 2011 after claiming the World Cup overall title in super-G in 2010. Last season, he passed Steve Podborski for the most career World Cup medals won by a Canadian and now sits at 22. ' ' '